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Comment
. 2007 Nov 5;179(3):371-3.
doi: 10.1083/jcb.200710021. Epub 2007 Oct 29.

Getting a G--RRP on regulated exocytosis in the heart

Christopher C Glembotski  1
Affiliations
Comment

Getting a G--RRP on regulated exocytosis in the heart

Christopher C Glembotski. J Cell Biol. .

Abstract

A study by Rybkin et al. (see p. 527) substantially advances our understanding of regulated exocytois by specialized secretory cells, such as atrial myocytes. A second member of the Ras-related protein family, RRP17, was identified and shown to participate in regulating the secretion of the cardiac-derived peptide hormone, atrial natriuretic peptide. In addition to the heart, RRP17 was shown to be expressed in neuronal, pancreatic, and skeletal muscle cells, suggesting a widespread role in regulated secretion for this new protein.

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Figures

Figure 1.
Figure 1.
Summary of regulated exocytosis of ANP from atrial myocytes. Shown is the hypothetical subcellular route of ANP packaging into LDCVs, as well as the co-secretional processing of pro-ANP to ANP by corin (Chan et al., 2005). The hypothetical involvement of various SNAREs, Ras-related small GTPases, and many other proteins, including CAPS1 (yellow), is shown. The involvement of RRP17 (magenta) and CAPS1 in calcium-dependent regulated exocytosis of LDCVs in the heart is the topic of the study by Rybkin et al. (2007).
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