[Morphological study of the trigonal epithelium in male hyperestrogenism]

Abstract

The histological changes caused by endocrinological action on the female epithelium are known and well-documented. These have been described in the bladder and attention has been focussed to the anatomo-clinical implications. A review of the literature with special reference to organogenetic, clinical and hormonal aspects prompted us to consider the cervico-trigonal epithelium as being particularly interesting in determining the histological changes arising from endocrine action. With hormonal influence as our working hypothesis, a morphological study of the trigonal epithelium was conducted in males with hyperestrogenism. Light and scanning electron microscopy revealed the presence of new glandular-like structures resembling the female endometrium with clearly evident metaplastic etiology and dynamics mediated by hormonal action.