Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Nov;26(5):1190-7.
doi: 10.1002/jmri.21135.

Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis

Hale Ersoy  1 , Frank J Rybicki
Affiliations
Review

Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis

Hale Ersoy et al. J Magn Reson Imaging. 2007 Nov.

Abstract

Gadolinium (Gd)-based paramagnetic contrast agents are relatively safe when used in clinically recommended doses. However, with the rapidly expanding body of literature linking Gd-based paramagnetic contrast agents and nephrogenic systemic fibrosis (NSF), awareness of the potential side effects and adverse reactions from Gd is now an important requirement for practicing radiologists. In addition to the ongoing accumulation and analyses of clinical NSF data, it is also essential for the practicing radiologist to understand the biochemical characteristics of the extracellular Gd-chelates. The purpose of this review is to consolidate and update the available information on known side effects, adverse reactions, and toxicity of the Gd chelates, with particular emphasis on the potential mechanisms of NSF.

PubMed Disclaimer

References

    1. Bousquet JC, Saini S, Stark DD, et al. Gd-DOTA: characterization of a new paramagnetic complex. Radiology. 1988;166:693–698. - PubMed
    1. Cacheris W, Quay S, Rocklage S. The relationship between thermodynamics and the toxicity of gadolinium complexes. Magn Reson Imaging. 1990;8:467–481. - PubMed
    1. Chang C. Magnetic resonance imaging contrast agents. Design and physicochemical properties of gadodiamide. Invest Radiol. 1993;28 Suppl 1:S21–S27. - PubMed
    1. Participant Summary Report of the College of American Pathologists Chemistry Survey C-C2001. Northfield, IL: College of American Pathologists; 2001. p. 18.
    1. Corot C, Idee JM, Hentsch AM, et al. Structure-activity relationship of macrocyclic and linear gadolinium chelates: investigation of transmetallation effect on the zinc-dependent metallopeptidase angiotensin-converting enzyme. J Magn Reson Imaging. 1998;8:695–702. - PubMed

MeSH terms