GABA in regulation of communicative activity and sexual motivation of male mice with different psychoemotional status

Abstract

We studied the effects of drugs modulating GABA content in the brain on communicative activity and sexual motivation of male mice. The effects of the drug depended on animal genotype and initial psychoemotional status. Aminooxyacetic acid elevating GABA content did not modulate communicative activity of intact males, reduced it in aggressive animals, restored in anxious animals, and promoted exhaustion of sexual motivation in anxious animals. Thiosemicarbazide reducing GABA level produced an anxiogenic effect and destabilized sexual motivation in intact males.