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. 2007 Nov;8(11):815-21.
doi: 10.1631/jzus.2007.B0815.

WOMBAT: a tool for mixed model analyses in quantitative genetics by restricted maximum likelihood (REML)

Karin Meyer  1
Affiliations

WOMBAT: a tool for mixed model analyses in quantitative genetics by restricted maximum likelihood (REML)

Karin Meyer. J Zhejiang Univ Sci B. 2007 Nov.

Abstract

WOMBAT is a software package for quantitative genetic analyses of continuous traits, fitting a linear, mixed model; estimates of covariance components and the resulting genetic parameters are obtained by restricted maximum likelihood. A wide range of models, comprising numerous traits, multiple fixed and random effects, selected genetic covariance structures, random regression models and reduced rank estimation are accommodated. WOMBAT employs up-to-date numerical and computational methods. Together with the use of efficient compilers, this generates fast executable programs, suitable for large scale analyses. Use of WOMBAT is illustrated for a bivariate analysis. The package consists of the executable program, available for LINUX and WINDOWS environments, manual and a set of worked example, and can be downloaded free of charge from (http://agbu. une.edu.au/~kmeyer/wombat.html).

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Figures

Fig. 1
Fig. 1
Parameter file for example
Fig. 2
Fig. 2
Summary of pedigree information for example
Fig. 3
Fig. 3
Estimates of covariance components and genetic parameters for example
Fig. 4
Fig. 4
Fixed effects solution for example
See this image and copyright information in PMC

References

    1. Dennis JE, Schnabel RB. Numerical Methods for Unconstrained Optimization and Nonlinear Equations. SIAM Classics in Applied Mathematics. Philadelphia: Society for Industrial and Applied Mathematics; 1996.
    1. Gilmour AR, Gogel DJ, Cullis BR, et al. ASReml User Guide Release 2.0. Hemel Hempstead, HP1 1ES, U: VSN International Ltd.; 2006. p. 342.
    1. Karypis G, Kumar V. METIS, a Software Package for Partitioning Unstructured Graphs, Partitioning Meshes, and Computing Fill-in Reducing Ordering of Sparse Matrices Version 4.0. Minneapolis: Department of Computer Science, University of Minnesota; 1998. p. 44.
    1. Kovacs MA, Groeneveld E. VCE-5 User’s Guide and Reference Manual, Version 5.1. Mariensee,Germany: Institute of Animal Husbandry and Animal Behaviour, Federal Research Center of Agriculture; 2003. p. 68.
    1. Liu C, Rubin DB, Wu YN. Parameter expansions to accelerate EM: the PX-EM algorithm. Biometrika. 1998;85(4):755–770. doi: 10.1093/biomet/85.4.755. - DOI

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