doi: 10.1021/jo7020357.
Epub 2007 Nov 2.
Functionalized chiral ionic liquid catalyzed enantioselective desymmetrizations of prochiral ketones via asymmetric Michael addition reaction
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- PMID: 17975933
- DOI: 10.1021/jo7020357
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Functionalized chiral ionic liquid catalyzed enantioselective desymmetrizations of prochiral ketones via asymmetric Michael addition reaction
J Org Chem.
.
Abstract
Functionalized chiral ionic liquids were found to be highly effective and reusable organocatalysts for asymmetric Michael additions of 4-substituted cyclohexanones. The desymmetrization reaction afforded the desired Michael adducts bearing three carbon stereocenters with up to 99% ee.
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