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Review
. 2008 May;66(2):91-8.
doi: 10.1016/j.critrevonc.2007.09.003. Epub 2007 Oct 31.

Role of insulin-like growth factor-1R system in colorectal carcinogenesis

Erin A Donovan  1 , Shivaani Kummar
Affiliations
Review

Role of insulin-like growth factor-1R system in colorectal carcinogenesis

Erin A Donovan et al. Crit Rev Oncol Hematol. 2008 May.

Abstract

The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.

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Figures

Figure 1
Figure 1
Insulin-like growth factor I receptor (IGF-1R): IGF-1R is a tyrosine kinase cell-surface receptor containing two α and two β subunits joined by disulfide bridges forming a heterotetrameric receptor complex. When ligand binds to IGF-1R, a conformational change occurs, leading to trans-autophosphorylation of the cytoplasmic tyrosine kinase domain, resulting in activation of the PI3K and Raf/MAPK pathways. [PI3K, phosphatidylinositol 3-kinase; TOR, target of rapamycin; MEK, mitogen-activated protein kinase kinase; ERK, extracellular signal-regulated kinase; Raf/MAPK, RAF-mitogen-activated protein kinase]
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