Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Feb;31(2):361-2.
doi: 10.2337/dc07-1276. Epub 2007 Oct 31.

High serum uric acid as a novel risk factor for type 2 diabetes

Abbas Dehghan  1 , Mandy van Hoek, Eric J G Sijbrands, Albert Hofman, Jacqueline C M Witteman
Affiliations

High serum uric acid as a novel risk factor for type 2 diabetes

Abbas Dehghan et al. Diabetes Care. 2008 Feb.

Abstract

Objective: To investigate the association between serum uric acid level and risk of type 2 diabetes.

Research design and methods: The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.

Results: The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively.

Conclusions: The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.

PubMed Disclaimer

Comment in

Publication types