High serum uric acid as a novel risk factor for type 2 diabetes
- PMID: 17977935
- DOI: 10.2337/dc07-1276
High serum uric acid as a novel risk factor for type 2 diabetes
Abstract
Objective: To investigate the association between serum uric acid level and risk of type 2 diabetes.
Research design and methods: The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.
Results: The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively.
Conclusions: The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.
Comment in
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Uric acid indicates a high cardiovascular risk profile but is not closely associated with insulin resistance in obese adolescents.Diabetes Care. 2008 Apr;31(4):e21. doi: 10.2337/dc07-2411. Diabetes Care. 2008. PMID: 18375422 No abstract available.
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High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al.Diabetes Care. 2008 Sep;31(9):e67. doi: 10.2337/dc08-0038. Diabetes Care. 2008. PMID: 18753663 No abstract available.
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High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al.Diabetes Care. 2008 Sep;31(9):e68. doi: 10.2337/dc08-0468. Diabetes Care. 2008. PMID: 18753664 No abstract available.
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