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. 2008 Jan;46(1):361-5.
doi: 10.1128/JCM.01561-07. Epub 2007 Oct 31.

Emergence of fluoroquinolone-resistant Haemophilus influenzae strains among elderly patients but not among children

Shin-ichi Yokota  1 , Yasuo Ohkoshi, Kiyoshi Sato, Nobuhiro Fujii
Affiliations

Emergence of fluoroquinolone-resistant Haemophilus influenzae strains among elderly patients but not among children

Shin-ichi Yokota et al. J Clin Microbiol. 2008 Jan.

Abstract

We screened 457 Haemophilus influenzae strains isolated in Japan during 2002 to 2004 and identified 12 fluoroquinolone-resistant strains (2.6%). The resistant strains were divided into three genotypes (eight, three, and one of each type). These were isolated from patients over 58 years of age. Several fluoroquinolone-resistant clones appeared to have invaded the population of elderly patients in a particular area, Sapporo city.

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Figures

FIG. 1.
FIG. 1.
RAPD-PCR analysis of fluoroquinolone resistance of H. influenzae clinical isolates. Lane M, size marker (pHY); lanes 1 to 8, genotype I strains (1, SRI68; 2, SRI182; 3, SRI131; 4, SRI126; 5, SRI97; 6, SRI26; 7, SRI183; 8, SRI186); lanes 9 to 11, genotype II strains (9, SRI38; 10, SRI181; 11, SRI177); lane 12, genotype III strain HUI313; lanes 13 to 18, strains susceptible to fluoroquinolones (13, SRI2; 14, SRI3; 15, SRI4; 16, SRI12; 17, SRI13; 18, SRI18). PCR primers used are indicated the top of each panel.
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References

    1. Biedenbach, D. J., and R. N. Jones. 2003. Five-year analysis of Haemophilus influenzae isolates with reduced susceptibility to fluoroquinolones: prevalence results from the SENTRY antimicrobial surveillance program. Diagn. Microbiol. Infect. Dis. 4655-61. - PubMed
    1. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M07-A7, 7th ed. Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Gensberg, K., Y. F. Jin, and L. J. Piddock. 1995. A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium. FEMS Microbiol. Lett. 13257-60. - PubMed
    1. Georgiou, M., R. Munoz, F. Roman, R. Canton, R. Gomez-Lus, J. Campos, and A. G. De La Campa. 1996. Ciprofloxacin-resistant Haemophilus influenzae strains possess mutations in analogous positions of GyrA and ParC. Antimicrob. Agents Chemother. 401741-1744. - PMC - PubMed
    1. Hasegawa, K., K. Yamamoto, N. Chiba, R. Kobayashi, K. Nagai, M. R. Jacobs, P. C. Appelbaum, K. Sunakawa, and K. Ubukata. 2003. Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States. Microb. Drug Resist. 939-46. - PubMed

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