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Comment
. 2007 Oct 31;27(44):11777-9.
doi: 10.1523/JNEUROSCI.4010-07.2007.

Parkinson's disease: fighting the will?

Yael Niv  1 , Michal Rivlin-Etzion
Affiliations
Comment

Parkinson's disease: fighting the will?

Yael Niv et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Velocity probability distributions of Parkinson's patients are shifted toward slower movements in all but the easiest conditions. Probability distribution functions for each condition were estimated using kernel density estimation based on all movements (valid and invalid) (see Mazzoni et al., 2007), and normalized [for non-normalized histograms, see Mazzoni et al. (2007), their Fig. 7 (http://www.jneurosci.org/cgi/content/full/27/27/7105/F7)]. In red are the estimated distributions for PD patients, in black are those for healthy controls. Shaded areas mark the required range of velocities in each condition [slow (S), 17–37 cm/s; medium (M), 37–57 cm/s; fast (F), 57–77 cm/s; very fast (VF), 77–97 cm/s], and numbers in bold (6,12, or 16) denote the distance to target in centimeters. Dashed line, Empirical mean. Data are courtesy of Dr. Pietro Mazzoni (Mazzoni et al., 2007)
See this image and copyright information in PMC

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References

    1. Heimer G, Rivlin-Etzion M, Bar-Gad I, Goldberg JA, Haber SN, Bergman H. Dopamine replacement therapy does not restore the full spectrum of normal pallidal activity in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine primate model of parkinsonism. J Neurosci. 2006;26:8101–8114. - PMC - PubMed
    1. Mazzoni P, Hristova A, Krakauer JW. Why don't we move faster? Parkinson's disease, movement vigor, and implicit motivation. J Neurosci. 2007;27:7105–7116. - PMC - PubMed
    1. Montague PR, Dayan P, Sejnowski TJ. A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J Neurosci. 1996;16:1936–1947. - PMC - PubMed
    1. Niv Y, Daw ND, Joel D, Dayan P. Tonic dopamine: opportunity costs and the control of response vigor. Psychopharmacology (Berl) 2007;191:507–520. - PubMed
    1. Salamone JD, Correa M. Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine. Behav Brain Res. 2002;137:3–25. - PubMed

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