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Review
. 2007 Oct 31;27(44):11856-9.
doi: 10.1523/JNEUROSCI.3624-07.2007.

Noncoding RNAs in the brain

John S Satterlee  1 , Scott Barbee, Peng Jin, Anna Krichevsky, Sofie Salama, Gerhard Schratt, Da-Yu Wu
Affiliations
Review

Noncoding RNAs in the brain

John S Satterlee et al. J Neurosci. .

Abstract

Cells transcribe thousands of RNAs that do not appear to encode proteins. The neuronal functions of these noncoding RNAs (ncRNAs) are for the most part not known, but specific ncRNAs have been shown to regulate dendritic spine development, neuronal fate specification and differentiation, and synaptic protein synthesis. ncRNAs have been implicated in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome. Future studies will likely identify additional neuronal functions for ncRNAs as well as roles for these molecules in other neuropsychiatric and neurodevelopmental disorders.

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