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Review
. 2007 Oct 31;27(44):11860-4.
doi: 10.1523/JNEUROSCI.3644-07.2007.

Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition

Adam R Aron  1 , Sarah Durston, Dawn M Eagle, Gordon D Logan, Cathy M Stinear, Veit Stuphorn
Affiliations
Review

Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition

Adam R Aron et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
A, The interactive race model between Go and Stop processes (Boucher et al., 2007). The parameters were estimated by fitting the model to thousands of behavioral trials from a monkey neurophysiology study. B, Schematic of fronto-basal-ganglia circuitry for Going and Stopping. The Go process is generated by premotor cortex, which excites striatum and inhibits globus pallidus, removing inhibition from thalamus and exciting motor cortex (see text for details). The stopping process could be generated by inferior frontal cortex leading to activation of the subthalamic nucleus, increasing broad excitation of pallidum and inhibiting thalamocortical output, reducing activation in motor cortex. C, Diffusion-weighted imaging reveals putative white matter tracts in the right hemisphere between the dorsomedial preSMA, the ventrolateral PFC or IFC, and the putative region of the STN. Reproduced with permission from Aron et al. (2007). D, Regions of the rat brain implicated in behavioral stopping. Stopping is significantly impaired following excitotoxic lesions within the regions highlighted in red, whereas lesions within the gray-colored regions have no effect on stopping. OF, Orbitofrontal cortex; IL, infralimbic cortex; PL, prelimbic cortex; DM Str, dorsomedial striatum; NAC, nucleus accumbens (core); DH, dorsal hippocampus; VH, ventral hippocampus; GPi, globus pallidus pars interna.
See this image and copyright information in PMC

References

    1. Aron AR, Poldrack RA. The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1285–1292. - PubMed
    1. Aron AR, Poldrack RA. Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus. J Neurosci. 2006;26:2424–2433. - PMC - PubMed
    1. Aron AR, Fletcher PC, Bullmore ET, Sahakian BJ, Robbins TW. Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nat Neurosci. 2003;6:115–116. - PubMed
    1. Aron AR, Monsell S, Sahakian BJ, Robbins TW. A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex. Brain. 2004;127:1561–1573. - PubMed
    1. Aron AR, Behrens TE, Smith S, Frank MJ, Poldrack RA. Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI. J Neurosci. 2007;27:3743–3752. - PMC - PubMed

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