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. 2007 Nov;30(11):2204-6.
doi: 10.1248/bpb.30.2204.

Enantioselective oxidation of enterodiol to enterolactone by human intestinal bacteria

Jong-Sik Jin  1 , Nobuko Kakiuchi, Masao Hattori
Affiliations
Free article

Enantioselective oxidation of enterodiol to enterolactone by human intestinal bacteria

Jong-Sik Jin et al. Biol Pharm Bull. 2007 Nov.
Free article

Abstract

In the course of our experiments on the metabolic conversion of lignans to the estrogenic substances enterodiol (END) and enterolactone (ENL) by human intestinal flora, we isolated two anaerobes, Ruminococcus sp. END-1 and strain END-2, capable of oxidizing END. The former selectively converted (-)-END to (-)-ENL, while the latter selectively converted (+)-END to (+)-ENL, indicating enantioselective oxidation by intestinal bacteria.

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