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. 2007 Oct 30;12(10):2413-26.
doi: 10.3390/12102413.

Antibacterial activity of some 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones: synthesis and preliminary QSAR studies

Ashis Kumar Nanda  1 , Subarna Ganguli, Ranadhir Chakraborty
Affiliations

Antibacterial activity of some 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones: synthesis and preliminary QSAR studies

Ashis Kumar Nanda et al. Molecules. .

Abstract

Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett's sigma constants and the substituent's molar refractivity.

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Figures

Scheme 1
Scheme 1
Figure 1
Figure 1
Juxtaposed pictures of the 2D-NMR spectra of compound 3j.
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