Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Sep-Oct;11(5):935-44.
doi: 10.1111/j.1582-4934.2007.00106.x.

Stem cell differentiation and expansion for clinical applications of tissue engineering

Pascale V Guillot  1 , Wei Cui, Nicholas M Fisk, Dame Julia Polak
Affiliations
Review

Stem cell differentiation and expansion for clinical applications of tissue engineering

Pascale V Guillot et al. J Cell Mol Med. 2007 Sep-Oct.

Abstract

This invited review discusses the latest advances stem cell biology, tissue engineering and the transition from bench to bedside. An overview is presented as to which the best cell source might be for cell therapy and tissue engineering applications, best biomaterials currently available and the challenges the field faces to translate basic research into therapies for a large number of human diseases.

PubMed Disclaimer

Figures

2
2
Human first trimester foetal mesenchymal stem cell present a fibroblastic spindle-like morphology visualized by crystal violet staining (A), are readily expandable (B) and express oct-4 (C), nanog (D) and hTERT both in the nucleus (active fraction) and in the cytoplasm (trafficking fraction) (E).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Langer R, Vacanti JP. Tissue engineering. Science. 1993;260:920–6. - PubMed
    1. Leor J, Amsalem Y, Cohen S. Cells, scaffolds and molecules for myocardial tissue engineering. Pharmacol Ther. 2005;105:151–63. - PubMed
    1. Levenberg S, Burdick JA, Kraehenbuehl T, Langer R. Neurotrophin-induced differentiation of human embryonic stem cells on three-dimensional polymeric scaffolds. Tiss Eng. 2005;11:506–12. - PubMed
    1. Khademhosseini A, Langer R, Borenstein J, Vacanti JP. Microscale technologies for tissue engineering and biology. Proc Nat Acad Sci. USA. 2006;103:2480–7. - PMC - PubMed
    1. Bienaime C, Barbotin JN, Nava-Saucedo JE. How to build an adapted and bioactive cell microenvironment? A chemical interaction study of the structure of Ca-alginate matrices and their repercussion on confined cells. J Biomed Mat Res Part A. 2003;67A:376–88. - PubMed