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Review
. 2007 Nov 2;131(3):437-40.
doi: 10.1016/j.cell.2007.10.024.

Limiting the proliferation of polyploid cells

Neil J Ganem  1 , David Pellman
Affiliations
Free article
Review

Limiting the proliferation of polyploid cells

Neil J Ganem et al. Cell. .
Free article

Abstract

Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid cells. Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells.

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