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Comment
. 2007 Nov;13(5):601-603.
doi: 10.1016/j.devcel.2007.10.009.

CYLD: a DUB with many talents

Sara J S Simonson  1 , Zhao-Hui Wu  1 , Shigeki Miyamoto  2
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CYLD: a DUB with many talents

Sara J S Simonson et al. Dev Cell. 2007 Nov.
Free article

Abstract

The deubiquitinating enzyme CYLD is a tumor suppressor protein known for its role in repression of generally pro-oncogenic NF-kappaB activation pathways. Two new studies published in this and the September issue of Developmental Cell show that CYLD dismantles distinct types of polyubiquitin chains formed on select signaling proteins and is thereby required for normal vertebrate and invertebrate development.

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