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Review
. 2007 Dec 28;282(52):37293-7.
doi: 10.1074/jbc.R700038200. Epub 2007 Nov 2.

Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae

George M Carman  1 , Susan A Henry
Affiliations
Review

Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae

George M Carman et al. J Biol Chem. .
No abstract available

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Figures

FIGURE 1
FIGURE 1. Structure of PA and its role in lipid synthesis
The structure of PA is shown with fatty acyl groups of 16:0 (sn-1) and 18:1 (sn-2). The pathways shown for the synthesis of glycerophospholipids include the relevant steps discussed in this review. A more comprehensive pathway of lipid metabolism may be found in Ref. . The genes that encode the enzymes catalyzing individual steps in the pathway are indicated. The UASINO-containing genes that are subject to regulation by inositol supplementation and to nutrient depletion are highlighted in blue. Gro, glycerol; Ins, inositol; PME, phosphatidylmonomethylethanolamine; PDE, phosphatidyldimethylethanolamine; Etn, ethanolamine; P-Etn, phosphoethanolamine; Cho, choline; P-Cho, phosphocholine.
FIGURE 2
FIGURE 2. Model for the role of PA in the transcriptional regulation of UASINO-containing genes
A, UASINO-containing genes (blue) are maximally expressed (thick arrow) when wild-type S. cerevisiae cells are grown in the absence of inositol and in the presence of sufficient amounts of essential nutrients. B, when inositol is added to the growth medium or when cells are depleted of an essential nutrient, transcription of UASINO-containing genes is attenuated (thin arrow) by the interaction of Opi1p with Ino2p. Dissociation of Opi1p from the nuclear/ER membrane is caused by a decrease in PA concentration, which is mediated by the stimulation of PI synthesis and by activation of Mg2+-dependent PA phosphatase (PAP1, denoted by the star). Etn, ethanolamine; Cho, choline; Ins, inositol.
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