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Case Reports
. 2007 Oct;22(5):918-22.
doi: 10.3346/jkms.2007.22.5.918.

A case of intestinal Behcet's disease similar to Crohn's colitis

Eun-Sun Kim  1 , Woo-Chul Chung, Kang-Moon Lee, Bo-In Lee, Hwang Choi, Sok-Won Han, Kyu-Yong Choi, In-Sik Chung
Affiliations
Case Reports

A case of intestinal Behcet's disease similar to Crohn's colitis

Eun-Sun Kim et al. J Korean Med Sci. 2007 Oct.

Abstract

Behcet's disease is a multi-systemic vasculitis and characterized by systemic organ involvement. Although the gastrointestinal and systemic features of Behcet's disease and inflammatory bowel disease overlap to a considerable extent, they are generally viewed as two distinct diseases. A 39-yr-old female was diagnosed as having Behcet's disease. She was admitted to our hospital because of oral and genital ulcer, lower abdominal pain, and frequent diarrhea. Colonoscopy showed diffuse involvement of multiple longitudinal ulcers with inflammatory pseudopolyps with a cobblestone appearance and ano-rectal fistula was suspected. These findings are extremely rare in Behcet's disease. However, there were no granulomas, the hallmark of Crohn's colitis. Microscopically, perivasculitis and multiple lymph follicles compatible with Behcet's disease were seen. Although being rarely encountered, multiple longitudinal ulcers, cobblestone appearance, and ano-rectal fistula can develop in Behcet's disease, as in Crohn's colitis. Therefore, Behcet's disease and Crohn's disease may be closely related and part of a spectrum of disease.

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Figures

Fig. 1
Fig. 1
The external genitalia showed a linear to ovoid shaped ulcerating wound at the perineum and vulva area.
Fig. 2
Fig. 2
Colonoscopic findings revealed grossly normal-appearing mucosa in the terminal ileum (A). Multiple longitudinal ulcers and inflammatory pseudopolyps with a cobblestone appearance were observed in the ascending, transverse, and descending colon. However, the Ileocecal valve was preserved from the inflammation (B, C). A suspicious fistular opening just above the anus was observed (D).
Fig. 3
Fig. 3
Microscopic examination from ulcers of the colon showed shallow ulcerations with inflammatory infiltration consisting of lymphocytes and plasma cells. There were no granulmas (A: H&E stain, ×100; B: H&E stain, ×200).
Fig. 4
Fig. 4
Microscopic examination of the perineal lesion revealed chronic ulcer with acute and chronic inflammatory cell infiltration and increased small blood vessels (A: H&E stain, ×100; B: H&E stain, ×400).
See this image and copyright information in PMC

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