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. 2007 Dec;39(12):1431-3.
doi: 10.1038/ng.2007.32. Epub 2007 Nov 4.

Rheumatoid arthritis association at 6q23

Wendy Thomson  1 , Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce; Wellcome Trust Case Control Consortium; Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery; YEAR Consortium; Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan, Jane Worthington
Collaborators, Affiliations

Rheumatoid arthritis association at 6q23

Wendy Thomson et al. Nat Genet. 2007 Dec.

Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

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References

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