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Editorial
. 2007 Nov;6(5):341-3.
doi: 10.1016/j.cmet.2007.10.004.

Nampt/PBEF/Visfatin: a new player in beta cell physiology and in metabolic diseases?

Tomohiro Tanaka  1 , Yo-Ichi Nabeshima
Affiliations
Free article
Editorial

Nampt/PBEF/Visfatin: a new player in beta cell physiology and in metabolic diseases?

Tomohiro Tanaka et al. Cell Metab. 2007 Nov.
Free article

Abstract

NAD plays an essential role in a number of biological processes. A study in this issue of Cell Metabolism (Revollo et al., 2007b) demonstrates that nicotinamide phosphoribosyltransferase (Nampt), also known as PBEF or visfatin, is a secreted enzyme and a source of systemic NAD. The authors show that Nampt-mediated NAD synthesis is necessary for beta cell function, providing fresh insights into the pathophysiology of metabolic diseases.

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