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Editorial
. 2007 Nov;6(5):343-5.
doi: 10.1016/j.cmet.2007.10.003.

DisSIRTing on LXR and cholesterol metabolism

Jerome N Feige  1 , Johan Auwerx
Affiliations
Free article
Editorial

DisSIRTing on LXR and cholesterol metabolism

Jerome N Feige et al. Cell Metab. 2007 Nov.
Free article

Abstract

The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.

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