doi: 10.1021/jo701859a.
Epub 2007 Nov 8.
Direct one-pot synthesis of alpha-siloxy-Weinreb amides from aldehydes
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- PMID: 17988149
- DOI: 10.1021/jo701859a
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Direct one-pot synthesis of alpha-siloxy-Weinreb amides from aldehydes
J Org Chem.
.
Abstract
A one-pot method for synthesizing alpha-siloxy-Weinreb amides from aldehydes was developed with use of N,O-dimethylhydroxylamine and a masked acyl cyanide reagent bearing a tert-butyldimethylsilyl group avoiding the competitive reaction toward N-methoxy-N-methyl-2-amino-1-siloxymalononitrile.
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