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. 2008 Feb 1;39(3):973-8.
doi: 10.1016/j.neuroimage.2007.09.045. Epub 2007 Oct 5.

Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI

Ze Wang  1 , María Fernández-Seara, David C Alsop, Wen-Ching Liu, Judy F Flax, April A Benasich, John A Detre
Affiliations

Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI

Ze Wang et al. Neuroimage. .

Abstract

Arterial spin labeled (ASL) perfusion MRI provides a noninvasive approach for longitudinal imaging of regional brain function in infants. In the present study, continuous ASL (CASL) perfusion MRI was carried out in normally developing 7- and 13-month-old infants while asleep without sedation. The 13-month infant group showed an increase (P<0.05) of relative CBF in frontal regions as compared to the 7-month group using a region of interest based analysis. Using a machine-learning algorithm to automatically classify the relative CBF maps of the two infant groups, a significant (P<0.05, permutation testing) regional CBF increase was found in the hippocampi, anterior cingulate, amygdalae, occipital lobes, and auditory cortex in the 13-month-old infants. These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function.

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Figures

Figure 1
Figure 1
Relative CBF maps (normalized to 50 ml/100g/min) from 7 month old (n=8, TOP) and 13 month old (n=8, MIDDLE) infants, along with a difference image showing increased CBF in frontal regions with development (BOTTOM).
Figure 2
Figure 2
ROI analysis showing changes in relative CBF within sensorimotor, visual, auditory, and frontal regions.
Figure 3
Figure 3
The spatial relative CBF discrepancy map between the 13-month group and 7-month group. Red means greater in the 13-month group; blue means greater in the 7-month group. A) whole brain perfusion discrepancy map without thresholding, B) suprathresholded perfusion difference map with cluster size greater than 80; the threshold for permutation probability is P<0.05.
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References

    1. Alsop DC, Detre JA. Multisection Cerebral Blood Flow MR Imaging with Continuous Arterial Spin Labeling. Radiology. 1998;208:410–416. - PubMed
    1. Alsop DC, Detre JA, Grossman M. Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging. Annals of neurology. 2000;47:93–100. - PubMed
    1. Biagi L, Abbruzzese A, Bianchi MC, Alsop DC, Guerra AD, Tosetti M. Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling. J Magn Reson Imaging. 2007;25(4):696–702. - PubMed
    1. Biswal BB, Ulmer JL. Blind source separation of multiple signal sources of fMRI data sets using independent component analysis. Journal of Computer Assisted Tomography. 1999;23:265–271. - PubMed
    1. Burges CJC. A Tutorial on Support Vector Machines for Pattern Recognition. Data Mining and Knowledge Discovery. 1998;2:121–167.

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