Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Dec 1;45(11):1518-21.
doi: 10.1086/522986. Epub 2007 Oct 22.

Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries

Antiretroviral Therapy in Low-Income Countries Collaboration of the International epidemiological Databases to Evaluate AIDS (IeDEA)  1 ; ART Cohort Collaboration; Martin W G Brinkhof, Matthias Egger, Andrew Boulle, Margaret May, Mina Hosseinipour, Eduardo Sprinz, Paula Braitstein, François Dabis, Peter Reiss, David R Bangsberg, Martin Rickenbach, Jose M Miro, Landon Myer, Amanda Mocroft, Denis Nash, Olivia Keiser, Margaret Pascoe, Stefaan van der Borght, Mauro Schechter
Affiliations

Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries

Antiretroviral Therapy in Low-Income Countries Collaboration of the International epidemiological Databases to Evaluate AIDS (IeDEA) et al. Clin Infect Dis. .

Abstract

We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.

PubMed Disclaimer

Conflict of interest statement

All other authors: no conflicts.

Figures

Figure 1
Figure 1
Incidence rate ratios of new tuberculosis events during the first year of HAART in low-income and high-income settings.
See this image and copyright information in PMC

Comment in

References

    1. World Health Organization. [Accessed April 2007];Towards universal access by 2010: how WHO is working with countries to scale-up HIV prevention, treatment, care and support. Available at http://www.who.int/hiv/toronto2006/towardsuniversalaccess.pdf.
    1. Ivers LC, Kendrick D, Doucette K. Efficacy of antiretroviral therapy programs in resource-poor settings: a meta-analysis of the published literature. Clin Infect Dis. 2005;41:217–224. - PubMed
    1. Braitstein P, Brinkhof MW, Dabis F, et al. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006;367:817–824. - PubMed
    1. Lawn SD, Bekker LG, Miller RF. Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet Infect Dis. 2005;5:361–373. - PubMed
    1. Dabis F, Balestre E, Braitstein P, et al. Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts. Int J Epidemiol. 2005;34:979–986. - PubMed

Substances