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Comment
. 2007 Nov 13;104(46):17907-8.
doi: 10.1073/pnas.0709010104. Epub 2007 Nov 8.

A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide

David J Lefer  1
Affiliations
Comment

A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide

David J Lefer. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: The author is currently funded by Ikaria Corporation for a research grant and serves as a paid Consultant for Ikaria Corporation. Ikaria is currently developing hydrogen sulfide therapy for a number of disease states.

Figures

Fig. 1.
Fig. 1.
Summary of the physiological actions of hydrogen sulfide (H2S). H2S is produced in micromolar (i.e., 10–100 μM) concentrations in the circulation and exerts a number of critical effects on the CV system. H2S has been shown to induce vasodilation and inhibit leukocyte-endothelial cell interactions in the circulation. H2S is a potent antioxidant and inhibits cellular apoptosis. H2S also has been shown to transiently and reversibly inhibit mitochondrial respiration. Taken together, this physiological profile is ideally suited for protection of the CV system against disease states.
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Comment on

  • Hydrogen sulfide mediates the vasoactivity of garlic.
    Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW. Benavides GA, et al. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17977-82. doi: 10.1073/pnas.0705710104. Epub 2007 Oct 19. Proc Natl Acad Sci U S A. 2007. PMID: 17951430 Free PMC article.

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