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. 2008;47(1):173-6.
doi: 10.1002/anie.200704392.

Au-Fe3O4 dumbbell nanoparticles as dual-functional probes

Chenjie Xu  1 , Jin Xie, Don Ho, Chao Wang, Nathan Kohler, Edward G Walsh, Jeffrey R Morgan, Y Eugene Chin, Shouheng Sun
Affiliations

Au-Fe3O4 dumbbell nanoparticles as dual-functional probes

Chenjie Xu et al. Angew Chem Int Ed Engl. 2008.
No abstract available

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Figures

Figure 1
Figure 1
a) Schematic illustration of surface functionalization of the Au-Fe3O4 nanoparticles. b, c) TEM images of the 8-20-nm Au-Fe3O4 particles before (b) and after (c) surface modification.
Figure 2
Figure 2
a) Magnetic hysteresis loops of the dumbbell nanoparticles before and after surface modification. The reduction of saturation magnetization is due largely to the weight contribution from the nonmagnetic Au particles. b) Reflection spectra of 20-nm Fe3O4, 8-nm Au, 3-20-nm Au-Fe3O4, and 8-20-nm Au-Fe3O4 nanoparticles.
Figure 3
Figure 3
a) T2-weighted MRI images of i) 20-nm Fe3O4, ii) 3-20-nm Au-Fe3O4, iii) 8-20-nm Au-Fe3O4 nanoparticles, and iv) A431 cells labeled with 8-20-nm Au-Fe3O4 nanoparticles. b) Reflection images of the A431 cells labeled with 8-20-nm Au-Fe3O4 nanoparticles. c, d) Images of A431 cells labeled with 8-20-nm dumbbell particles, floating in the medium before (c) and after (d) an external magnetic field was applied (field gradient in the sample area was in 500-100 G). The dashed circles denote individual cells; the numbers label the same cells in (c) and (d); the arrow and H indicate the direction of the applied magnetic field.
Figure 4
Figure 4
a) Reflection image of the labeled cells used to obtain Figure 3b after three days. b) Detection-limit examination of the 8-20-nm Au-Fe3O4-EGFRA labeled A431 cells. c) Reflection image of Fe3O4-labeled A431 cells. d) Reflection image of Au-Fe3O4 labeling without EGFR antibody.
See this image and copyright information in PMC

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