Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Nov-Dec;40(6 Suppl):S62-5.
doi: 10.1016/j.jelectrocard.2007.06.018.

Imaging fibrillation/defibrillation in a dish

Leslie Tung  1 , Joshua Cysyk
Affiliations
Review

Imaging fibrillation/defibrillation in a dish

Leslie Tung et al. J Electrocardiol. 2007 Nov-Dec.

Abstract

Background: Sheets of cultured cardiac cells constitute an emerging experimental model of cardiac tissue electrophysiology and arrhythmia. It has been used to study fundamental properties of reentrant (spiral) waves and electric field interactions with tissue structure and thus constitutes a valuable model for investigations of fibrillation and defibrillation.

Methods: Optical mapping can be used to visualize action potential propagation or calcium waves in confluent monolayers of neonatal rat ventricular cells. Spiral waves can be initiated by burst pacing and terminated by an electric field shock.

Results: Work from this laboratory and others is reviewed regarding the behavior of single and multiple spiral waves in this model system as they pertain to fibrillation (dynamic instabilities) and defibrillation (interaction of electric fields with reentrant waves).

Conclusions: Subject to limitations, the cultured cell monolayer is a controlled experimental model that will be useful for further study of basic aspects of fibrillation and defibrillations.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Corrado D, Basso C, Thiene G. Is it time to include ion channel diseases among cardiomyopathies? J Electrocardiol. 2005;38(Suppl):81. - PubMed
    1. Thiene G, Corrado D, Basso C. Cardiomyopathies: is it time for a molecular classification? Eur Heart J. 2004;25:1772. - PubMed
    1. Maron BJ, Towbin JA, Thiene G, et al. Contemporary definitions and classification of the cardiomyopathies. An American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006;113:1807. - PubMed
    1. Kleber AG, Rudy J. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev. 2004;84:431. - PubMed
    1. Bacharova L, Kyselovic J. Electrocardiographic diagnosis of left ventricular hypertrophy: is the method obsolete or should the hypothesis be reconsidered? Med Hypotheses. 2001;57:487. - PubMed

Publication types

MeSH terms