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Case Reports
. 2008 Mar;60(3):319-22.
doi: 10.1016/j.diagmicrobio.2007.09.017. Epub 2007 Nov 9.

Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 beta--lactamase-producing Klebsiella pneumoniae epidemic clone

Javier Cobo  1 , María-Isabel Morosini, Vicente Pintado, Marta Tato, Noemí Samaranch, Fernando Baquero, Rafael Cantón
Affiliations
Case Reports

Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 beta--lactamase-producing Klebsiella pneumoniae epidemic clone

Javier Cobo et al. Diagn Microbiol Infect Dis. 2008 Mar.

Abstract

We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-beta-lactamase (VIM-1) and an extended-spectrum beta-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone.

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