Cytokine regulation of hematopoietic stem cells

Abstract

Regulation of hematopoietic stem cell proliferation and differentiation is likely to be controlled by the local concentration of both inhibitory and stimulatory cytokines. A newly described regulator of early haematopoietic cells called mast cell growth factor, stem cell factor or kit ligand (referred to here as the Sl factor) has been described. This factor is the gene product of the murine Steel locus and is the ligand for the c-kit proto-oncogene, the product of the murine W locus. The effects of Sl factor on primitive hematopoietic cells suggest that this growth factor is a major stimulator of basal hemopoiesis. Further, data indicates that Sl factor acts in synergy with virtually all of the later acting growth factors to enhance the proliferative and differentiative potential of these cells.