U2 snRNP: not just for poly(A) mRNAs
- PMID: 17996698
- DOI: 10.1016/j.molcel.2007.10.015
U2 snRNP: not just for poly(A) mRNAs
Abstract
Polyadenylated mRNAs and replication-dependent histone mRNAs, which are not polyadenylated, share factors involved in 3' end formation. Friend et al. (2007) now report that the U2 snRNP, required for pre-mRNA splicing, is also required for histone mRNA 3' end formation.
Comment on
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U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation.Mol Cell. 2007 Oct 26;28(2):240-52. doi: 10.1016/j.molcel.2007.09.026. Mol Cell. 2007. PMID: 17964263 Free PMC article.
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