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Review
. 2007 Nov 15;84(9):1071-4.
doi: 10.1097/01.tp.0000287126.12083.48.

Interleukin-23 and TH17 cells in transplantation immunity: does 23+17 equal rejection?

Ye Chen  1 , Kathryn J Wood
Affiliations
Review

Interleukin-23 and TH17 cells in transplantation immunity: does 23+17 equal rejection?

Ye Chen et al. Transplantation. .

Abstract

Interleukin-23 (IL-23) and the recently discovered Th17 cells have been implicated in the pathogenesis of autoimmune diseases. This review will discuss current understanding of T-cell subsets in transplantation immunity and will explore the role of IL-23 and Th17 cells in allograft rejection, tolerance, and ischemia reperfusion injury.

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