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. 2007;9(5):338-45.
doi: 10.4088/pcc.v09n0502.

Morbidity associated with sleep disorders in primary care: a longitudinal cohort study

Mari-Ann Wallander  1 , Saga Johansson, Ana Ruigómez, Luis A García Rodríguez, Roger Jones
Affiliations

Morbidity associated with sleep disorders in primary care: a longitudinal cohort study

Mari-Ann Wallander et al. Prim Care Companion J Clin Psychiatry. 2007.

Abstract

Objective: Few epidemiologic studies evaluate the relative contribution of different risk factors on sleep problems. The aim of the present study was to assess demographics, comorbid characteristics, and health outcomes in patients with sleep disorders.

Method: A population-based cohort study with nested case-control analysis was conducted in adults using the U.K. General Practice Research Database. Information was collected for 12,437 patients with a new sleep disorder diagnosis during the year 1996 and 18,350 age- and sex-matched controls. Logistic regression analysis was used to compute odds ratios (OR) and 95% confidence intervals (CI).

Results: The incidence of a new sleep disorder diagnosis was 12.5 per 1000 person-years. There was a clear association of sleep disorders with smoking and excessive alcohol consumption; prior psychiatric disorders, including stress (OR = 3.6, 95% CI = 2.9 to 4.4) and depression (OR = 3.1, 95% CI = 2.8 to 3.3); prior circulatory diseases, including heart failure (OR = 1.8, 95% CI = 1.4 to 2.2) and coronary heart disease (OR = 1.4, 95% CI = 1.2 to 1.6); and prior gastrointestinal diseases, including gastroesopha-geal reflux disease (OR = 1.4, 95% CI = 1.2 to 1.7) and irritable bowel syndrome (OR = 1.5, 95% CI = 1.2 to 1.9). Use of hypnotics and anti-depressants was increased in the year after diagnosis. Relative 1-year mortality risk was 3-fold higher in the sleep disorder group than in controls, with a noticeably higher proportion of deaths due to suicide.

Conclusion: The fact that sleep disorders were associated with several morbidities, most strongly with psychiatric disorders as well as with increased mortality, underscores the importance of sleep problems as indicators of health status.

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Figures

Figure 1.
Figure 1.
The Incidence of Sleep Disorders, Calculated According to Age and Sex
See this image and copyright information in PMC

References

    1. Bixler EO, Kales A, and Soldatos CR. et al. Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry. 1979 136:1257–1262. - PubMed
    1. National Sleep Foundation. 2002 Sleep in America Poll. Available at: http://www.sleepfoundation.org/site/c.huIXKjM0IxF/b.2417355/k.143E/2002_.... Accessed Apr 12, 2007.
    1. Stewart R, Besset A, and Bebbington P. et al. Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years. Sleep. 2006 29:1391–1397. - PubMed
    1. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6:97–111. - PubMed
    1. National Center on Sleep Disorders Research. 1994. Available at: http://www.nhlbi.nih.gov/health/prof/sleep/sleep.txt. Accessed Feb 27, 2006.