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Review
. 2007 Nov;9(6):470-6.
doi: 10.1007/BF02938391.

Aliskiren: the first direct renin inhibitor for hypertension

Anton H van den Meiracker  1 , A H Jan Danser
Affiliations
Review

Aliskiren: the first direct renin inhibitor for hypertension

Anton H van den Meiracker et al. Curr Cardiol Rep. 2007 Nov.

Abstract

Aliskiren is the first member of a novel class of antihypertensive agents, the renin inhibitors, that has been approved by the US Food and Drug Administration for the treatment of hypertension. This review discusses its potential differences compared with existing renin-angiotensin-aldosterone system blockers, focusing also on the inactive precursor of renin, prorenin, and the recently discovered (pro)renin receptor. The review summarizes the findings from all clinical trials with aliskiren published so far, and provides an overview of the safety and tolerability of the new drug.

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