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. 2008 Jan;36(Database issue):D637-40.
doi: 10.1093/nar/gkm1001. Epub 2007 Nov 13.

The BioGRID Interaction Database: 2008 update

Bobby-Joe Breitkreutz  1 , Chris Stark, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Michael Livstone, Rose Oughtred, Daniel H Lackner, Jürg Bähler, Valerie Wood, Kara Dolinski, Mike Tyers
Affiliations

The BioGRID Interaction Database: 2008 update

Bobby-Joe Breitkreutz et al. Nucleic Acids Res. 2008 Jan.

Abstract

The Biological General Repository for Interaction Datasets (BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for both the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.

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Figures

Figure 1.
Figure 1.
Overlap between various high-throughput protein interaction datasets (11–13) and the literature-curated interaction dataset as of 1 January 2007 (2). Dataset manipulation was performed with the Osprey visualization system (10). All datasets are available for download from www.thebiogrid.org. N, interaction node and E, interaction edge.
See this image and copyright information in PMC

References

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    1. Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, et al. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J. Biol. 2006;5:11. - PMC - PubMed
    1. Batada NN, Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hurst LD, Tyers M. Stratus not altocumulus: a new view of the yeast protein interaction network. PLoS Biol. 2006;4:e317. - PMC - PubMed
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    1. Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D. The database of interacting proteins: 2004 update. Nucleic Acids Res. 2004;32:D449–D451. - PMC - PubMed

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