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Editorial
. 2007;9(5):108.
doi: 10.1186/ar2313.

Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis

Peter Ahnert, Holger Kirsten
Editorial

Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis

Peter Ahnert et al. Arthritis Res Ther. 2007.

Abstract

Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease.

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Comment on

  • The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study.
    Jacq L, Garnier S, Dieudé P, Michou L, Pierlot C, Migliorini P, Balsa A, Westhovens R, Barrera P, Alves H, Vaz C, Fernandes M, Pascual-Salcedo D, Bombardieri S, Dequeker J, Radstake TR, Van Riel P, van de Putte L, Lopes-Vaz A, Glikmans E, Barbet S, Lasbleiz S, Lemaire I, Quillet P, Hilliquin P, Teixeira VH, Petit-Teixeira E, Mbarek H, Prum B, Bardin T, Cornélis F; European Consortium on Rheumatoid Arthritis Families. Jacq L, et al. Arthritis Res Ther. 2007;9(4):R63. doi: 10.1186/ar2221. Arthritis Res Ther. 2007. PMID: 17615072 Free PMC article.

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