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Review
. 2008 Jan;15(1):21-34.
doi: 10.1128/CVI.00330-07. Epub 2007 Nov 14.

Lyme arthritis: current concepts and a change in paradigm

Dean T Nardelli  1 , Steven M Callister, Ronald F Schell
Affiliations
Review

Lyme arthritis: current concepts and a change in paradigm

Dean T Nardelli et al. Clin Vaccine Immunol. 2008 Jan.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Proposed mechanism for the development of Th17 cells and arthritis following infection with B. burgdorferi. Infection with B. burgdorferi stimulates the TLR-mediated release of proinflammatory cytokines, such as IL-6. IL-6, in combination with endogenous TGF-β, induces the development of Th17 cells from T-cell precursors. Th17 cells produce IL-17, which stimulates the production of other proinflammatory cytokines, such as IL-1β and TNF-α. IL-17 also induces from fibroblasts and synovial cells the production of IL-6, which serves to continue the inflammatory feedback loop. This process may occur until the borrelial load is reduced such that TLR-mediated production of IL-6 is insufficient to influence Th17 cell production.
See this image and copyright information in PMC

References

    1. Aggarwal, S., and A. L. Gurney. 2002. IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 71:1-8. - PubMed
    1. Akin, E., G. McHugh, R. Flavell, E. Fikrig, and A. Steere. 1999. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild brief arthritis. Infect. Immun. 67:173-181. - PMC - PubMed
    1. Akin, E., J. Aversa, and A. C. Steere. 2001. Expression of adhesion molecules in synovia of patients with treatment-resistant Lyme arthritis. Infect. Immun. 69:1774-1780. - PMC - PubMed
    1. Amlong, C. A., D. T. Nardelli, S. Heil Peterson, T. F. Warner, S. M. Callister, and R. F. Schell. 2006. Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice. Clin. Vaccine Immunol. 13:289-296. - PMC - PubMed
    1. Anguita, J., D. H. Persing, M. Rincón, S. W. Barthold, and E. Fikrig. 1996. Effect of anti-interleukin 12 treatment of murine Lyme borreliosis. J. Clin. Investig. 97:1028-1034. - PMC - PubMed