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. 2007 Dec 7:(45):4726-8.
doi: 10.1039/b714438e. Epub 2007 Oct 26.

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

Stefano Avedano  1 , Lorenzo Tei, Alberto Lombardi, Giovanni B Giovenzana, Silvio Aime, Dario Longo, Mauro Botta
Affiliations

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

Stefano Avedano et al. Chem Commun (Camb). .

Abstract

Two new GdEGTA (EGTA = ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecedented high relaxivity, close to that predicted by theory, interpreted in terms of the combined effect of restricted local rotation and fast rate of water exchange.

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