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Comment
. 2007 Apr 19;1(2):90-1.
doi: 10.1016/j.chom.2007.04.004.

A Reverse genetics system for dsRNA viruses

Ralph S Baric  1 , Amy C Sims
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A Reverse genetics system for dsRNA viruses

Ralph S Baric et al. Cell Host Microbe. .
Free article

Abstract

The advent of a new reverse genetics system for reoviruses, described in this issue of Cell Host & Microbe by Kobayashi et al., opens new horizons of investigation into the molecular mechanisms governing dsRNA virus replication and pathogenesis. The elegant approach for recombinant reovirus recovery from a set of plasmid DNAs provides a template for designing similar reverse genetics systems for other dsRNA viruses associated with considerable morbidity and mortality in humans.

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