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Comment
. 2007 Dec 14;318(5857):1730-1.
doi: 10.1126/science.1151360. Epub 2007 Nov 15.

Circadian rhythms. Daily watch on metabolism

Takato Imaizumi  1 , Steve A Kay, Julian I Schroeder
Affiliations
Comment

Circadian rhythms. Daily watch on metabolism

Takato Imaizumi et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. Metabolic feedback to clocks
(Left) The plant circadian clock comprises interlocking loops of the clock components CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), LATE ELONGATED HYPOCOTYL (LHY), PSEUDO-RESPONSE REGULATORs (PRRs), TIMING OF CAB EXPRESSION 1 (TOC1), and GIGANTEA (GI). The clock controls the concentration of cADPR, which in turn regulates circadian oscillation in the cytosolic free Ca2+ concentration. (Right) In the mammalian clock, the CLOCK/BMAL1 heterodimer regulates expression of PERIOD (PER), CRYPTOCHROME (CRY), RORA, and REV-ERBα. REV-ERBα is a heme sensor that forms a transcriptional repressor complex. Heme provides feedback to the circadian clock and influences gluconeogenesis.
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MeSH terms