US norms for six generic health-related quality-of-life indexes from the National Health Measurement study

Abstract

Background: A number of indexes measuring self-reported generic health-related quality-of-life (HRQoL) using preference-weighted scoring are used widely in population surveys and clinical studies in the United States.

Objective: To obtain age-by-gender norms for older adults on 6 generic HRQoL indexes in a cross-sectional US population survey and compare age-related trends in HRQoL.

Methods: The EuroQol EQ-5D, Health Utilities Index Mark 2, Health Utilities Index Mark 3, SF-36v2 (used to compute SF-6D), Quality of Well-being Scale self-administered form, and Health and Activities Limitations index were administered via telephone interview to each respondent in a national survey sample of 3844 noninstitutionalized adults age 35-89. Persons age 65-89 and telephone exchanges with high percentages of African Americans were oversampled. Age-by-gender means were computed using sampling and poststratification weights to adjust results to the US adult population.

Results: The 6 indexes exhibit similar patterns of age-related HRQoL by gender; however, means differ significantly across indexes. Females report slightly lower HRQoL than do males across all age groups. HRQoL seems somewhat higher for persons age 65-74 compared with people in the next younger age decade, as measured by all indexes.

Conclusions: Six HRQoL measures show similar but not identical trends in population norms for older US adults. Results reported here provide reference values for 6 self-reported HRQoL indexes.

FIGURE 1

Means estimating non-institutionalized US population health-related quality-of-life (HRQoL) by age are shown for males and females using 6 standardized indexes: EQ-5D, HUI2, HUI3, QWB-SA, SF-6D, and HALex. Cases were stratified by age range and gender and means computed within each stratum using survey-weighted regression of index scores on age centered to ages 40, 50, 60, 70, and 80 years as appropriate to the stratrum.