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. 2004 May 31;9(6):472-9.
doi: 10.3390/90600472.

Toward pyridine-fused selenium-containing antioxidants

Tahli Fenner  1 , Carl H Schiesser
Affiliations

Toward pyridine-fused selenium-containing antioxidants

Tahli Fenner et al. Molecules. .

Abstract

Photolysis of the thiohydroximate ester derivative 21 of 2-carboethoxy-2-(2- (benzylseleno)pyridin-3-yl)tridecylcarboxylic acid (20) affords 2-dodecyl-2- carboethoxy-2,3-dihydroselenolo[2,3-b]pyridine (22) in 89% yield in a process presumably involving intramolecular homolytic substitution by a tertiary alkyl radical at selenium with loss of a benzyl radical. Work toward extending this methodology to the preparation of pyridine-fused selenium analogues of antioxidants is described.

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Figure 1
Perspective diagram of 28
See this image and copyright information in PMC

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