Review
doi: 10.1038/nrg2227.
Cooperation of signalling pathways in embryonic mammary gland development
Affiliations
- PMID: 18007652
- DOI: 10.1038/nrg2227
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Review
Cooperation of signalling pathways in embryonic mammary gland development
Nat Rev Genet.
2007 Dec.
Erratum in
- Nat Rev Genet. 2008 Jul;9(7):566
Abstract
Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.
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