Methamphetamine-induced dopamine release in the medial frontal cortex of freely moving rats

Abstract

The effect of methamphetamine (MAP) on the efflux of endogenous dopamine (DA) in the medial frontal cortex of freely moving rats was evaluated by a microdialysis technique. The injection of MAP at 4 mg/kg, i.p., increased the extracellular levels of DA and decreased the levels of 3,4-dihydroxyphenylacetic acid significantly. Although the changes were smaller than those observed in the striatum, the direction and time course were similar. MAP increases the efflux of DA in the medial frontal cortex.