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Review
. 1991 Fall-Winter;38(3-4):179-88.

X-linkage and manic-depressive illness: a reassessment

M Baron  1
Affiliations
  • PMID: 1801199
Review

X-linkage and manic-depressive illness: a reassessment

M Baron. Soc Biol. 1991 Fall-Winter.

Abstract

Genetic-epidemiological data and linkage studies with chromosomal markers are reviewed from the vantage point of X-linked inheritance. The results overall suggest that a gene predisposing to manic depression (bipolar affective illness) localized on the X-chromosome may exist in a subgroup of bipolar cases. However, in light of conflicting findings and methodological uncertainties in studying a disorder with unclear phenotype and complex inheritance, this issue is not yet closed. Additional research, including new linkage data and extension and re-evaluation of published data, is required to further our understanding of this intriguing hypothesis.

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