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. 2007 Nov;26(11):1119-26.
doi: 10.1016/j.healun.2007.08.011.

Combined heart-kidney transplantation: the University of Wisconsin experience

Joshua L Hermsen  1 , Dilip S Nath, Alejandro Munoz del Rio, Joshua B Eickstaedt, Christopher Wigfield, Joshua D Lindsey, Niloo M Edwards
Affiliations

Combined heart-kidney transplantation: the University of Wisconsin experience

Joshua L Hermsen et al. J Heart Lung Transplant. 2007 Nov.

Abstract

Background: Combined heart-kidney transplantation (HKTx) is increasing in frequency, but long-term outcomes are unknown and appropriately comparative analysis is lacking.

Methods: This study was a retrospective review of prospectively collected data for 19 HKTx patients. Patient and graft survival, graft rejection and coronary allograft vasculopathy (CAV) were compared for HKTx vs recipients of a heart (n = 515) or kidney alone (n = 3,188) or both organs at separate time-points (n = 8).

Results: Patient and graft survival did not differ for HKTx vs any group. HKTx time to first rejection episode was significantly prolonged for both organs vs single-organ recipients. The incidence of CAV was significantly lower for HKTx.

Conclusions: HKTx provides outcomes similar to those for solitary heart or kidney transplantation. There may be an immunologic advantage to receiving organs in a combined fashion. Such allocation of organs seems medically appropriate; however, more refined strategies are needed to identify optimal recipient populations.

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