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Comment
. 2007 Nov 16;131(4):647-9.
doi: 10.1016/j.cell.2007.10.043.

Gaucher disease: forging a new path to the lysosome

Gillian M Griffiths  1
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Gaucher disease: forging a new path to the lysosome

Gillian M Griffiths. Cell. .
Free article

Abstract

Most lysosomal proteins are tagged with a carbohydrate modification that allows their recognition and transport to the lysosome. In this issue, Reczek et al. (2007) identify a new pathway for protein sorting to the lysosome. They show that beta-glucocerebrosidase-the lysosomal enzyme defective in patients with Gaucher disease-is delivered to the lysosome through its interaction with the transmembrane protein LIMP-2.

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