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Review
. 2007 Nov-Dec;9(14-15):1644-51.
doi: 10.1016/j.micinf.2007.09.004. Epub 2007 Sep 14.

Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases)

Gregory A Taylor  1 , Carl G Feng, Alan Sher
Affiliations
Free article
Review

Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases)

Gregory A Taylor et al. Microbes Infect. 2007 Nov-Dec.
Free article

Abstract

IRG proteins (also known as p47 GTPases) are key mediators of interferon-gamma-induced resistance to pathogens. Absence of certain IRG proteins leads to profound susceptibility to protozoa and bacteria in mice. Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hematopoiesis following infection.

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