On the mechanism of reduced tabletability of granules prepared by roller compaction
- PMID: 18024020
- DOI: 10.1016/j.ijpharm.2007.10.002
On the mechanism of reduced tabletability of granules prepared by roller compaction
Abstract
In a recent paper published in this journal, authors were perplexed by their results seemingly conflicting with our earlier findings [Sun, C.C., Himmelspach, M.W., 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J. Pharm. Sci. 95, 200-206]. After carefully reviewing the two studies, we conclude that results in the two studies are actually consistent with each other.
Comment on
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Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties.Int J Pharm. 2007 Jun 29;338(1-2):110-8. doi: 10.1016/j.ijpharm.2007.01.035. Epub 2007 Jan 28. Int J Pharm. 2007. PMID: 17324537
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