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. 2008 Jan 1;18(1):184-7.
doi: 10.1016/j.bmcl.2007.10.102. Epub 2007 Nov 1.

Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

Oscar Rebollo  1 , Esther del Olmo, Grace Ruiz, José L López-Pérez, Alberto Giménez, Arturo San Feliciano
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Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

Oscar Rebollo et al. Bioorg Med Chem Lett. .

Abstract

A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the microM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

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